Mechanisms of telomere elongation in aggressive pediatric medulloblastoma

Takeaway

  • Elongation of telomeres was activated in 42.8% of primary metastatic pediatric medulloblastomas (MBDs), induced by both TERT promoter mutations and hypermethylation, and the alternative lengthening of telomeres (ALT) mechanism triggered by ATRX inactivation.

Why this matters

  • While some studies have assessed the telomerase/ALT pathways in MBDs, this study focuses on tumors with metastatic dissemination at onset and the findings could contribute to developing targeted therapeutic strategies for molecular subsets of metastatic tumors.