Mechanistic elucidation of post-transcriptional polyadenylation in temporal lobe epilepsy

Takeaway

  • Cytoplasmic mRNA polyadenylation undergoes widespread reorganization in temporal lobe epilepsy (TLE).

Why this matters

    To date, alterations in mRNA polyadenylation, a post-transcriptional mechanism regulating gene expression, have not been studied in individuals with epilepsy and are not completely understood.