Metabolic abnormalities following a traumatic brain injury

Takeaway

  • Delivery of glucose to the brain is dependent on plasma glucose and cerebral blood flow in patients with traumatic brain injury (TBI).

Why this matters

  • Metabolic derangements in cerebral glucose metabolism are common in people with TBI. Changes in metabolism are likely influenced by a complex set of factors, including plasma glucose, cerebral blood flower, transport across the blood-brain barrier, entry into the glycolytic pathway, and metabolism.

  • Positron emission tomography (PET) scans with tracers for glucose and oxygen has been effectively used to image cerebral glucose metabolism, but a more nuanced understanding is warranted.