Delivery of glucose to the brain is dependent on plasma glucose and cerebral blood flow in patients with traumatic brain injury (TBI).
Why this matters
Metabolic derangements in cerebral glucose metabolism are common in people with TBI. Changes in metabolism are likely influenced by a complex set of factors, including plasma glucose, cerebral blood flower, transport across the blood-brain barrier, entry into the glycolytic pathway, and metabolism.
Positron emission tomography (PET) scans with tracers for glucose and oxygen has been effectively used to image cerebral glucose metabolism, but a more nuanced understanding is warranted.