Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model


  • Metabotropic glutamate receptor 5 (mGluR5) may contribute to the central sensitization of chronic migraine (CM) through regulation of synaptic plasticity via protein kinase C (PKC)/NR2B signaling; mGluR5 may therefore be a potential target for treatments for CM.

Why this matters

  • Central sensitization is considered to be the main pathological mechanism of CM. Previous studies have shown that synaptic plasticity contributes to central sensitization in CM and indicate that metabotropic glutamate receptors may regulate this synaptic plasticity.

  • It is therefore important to understand the role of metabotropic glutamate receptors in central sensitization in CM to identify a potential therapeutic candidate for CM.