Microbleed location and recovery of consciousness in severe traumatic brain injury


  • Microbleeds in patients with traumatic brain injury (TBI) were observed in variable combinations, and arousal mechanisms in the human brain showed resilience, with most of the study cohort recovering consciousness.

Why this matters ?

  • Coma in patients with severe TBI is thought to be caused by disruption of an ascending arousal network that links arousal nuclei in several regions of the brain.

  • It is unknown which arousal nuclei can be lesioned without affecting a patient’s ability to recover consciousness, which has profound clinical implications for patients with severe TBI.