Migraine chronification mediated by cortical and sub-cortical functional connectivity abnormalities

Takeaway

  • A greater understanding of the pathways that mediate severe clinical phenotypes in patients with migraine may help to develop targeted therapeutics for the condition.

Why this matters

    Approximately two-thirds of patients with migraine report the perception of pain induced by trivial stimuli to normal skin know as cutaneous allodynia (CA) which is a risk factor for migraine chronification.