Migraine-provoking substances and periorbital mechanical allodynia in mice

Takeaway

  • Substances that provoke migraines in people elicited periorbital mechanical allodynia (PMA) in mice, an effect that is not due solely to vasodilation and may involve the terminal regions of peripheral trigeminal fibers.

Why this matters

  • The alignment of migraine-provoking substances in people and mice may be helpful in elucidating the mechanisms of onset of migraines.