Mild cognitive impairment: how early does neuropsychological decline occur?


  • Cognitive and behavioral decline begin around 20 years before diagnosis of incident mild cognitive impairment (MCI).

Why this matters

  • Mild cognitive impairment (MCI) is often recognized as the earliest symptom of neurodegeneration in dementia and Alzheimer’s disease (AD).

  • Clarification of the timeline of MCI is important as early diagnosis and intervention could slow or even prevent further cognitive decline and progression of dementia and death.