Minor hallucinations and cognitive decline in Parkinson’s disease

Takeaway

  • Minor hallucinations may be an early clinical marker of increased neurodegeneration and are linked to mid-term subjective cognitive decline in de novo Parkinson’s disease (PD).

Why this matters

  • The predictive value of minor psychotic phenomena in PD is not well-established; cross-sectional studies allude to a link between minor hallucinations and more severe cortical atrophy, but there is a paucity of longitudinal and baseline studies in this area.

  • Identification of a potential early clinical marker for increased neurodegeneration and associated cognitive decline has important implications for early diagnosis and targeted therapy in high risk PD patients, and may improve patients’ quality of life.