Mitochondrial DNA genomic variation and Pick’s disease risk

Takeaway

  • Regarding Pick’s disease (PiD), mitochondrial DNA (mtDNA) variation is not a disease driver but may potentially influence susceptibility.

Why this matters

  • The genetic etiology of PiD (sporadic form of tauopathy-related frontotemporal dementia) is unknown; however, since mitochondria are involved in neurodegeneration and aging, and contain their own genome (mtDNA) which identifies individuals to specific haplogroups, mitochondrial health may be implicated.

  • The need to understand the association between tau aggregation, and mitochondrial health as determined by mtDNA factors is highlighted, as this may enhance current knowledge on the pathophysiology of PiD and potentially other tauopathies.