MMP-9 variants associated with hemorrhagic transformation in acute ischemic stroke patients


  • Hemorrhagic transformation (HT) is common in acute ischemic stroke (IS) in the Chinese population.

  • Two‐loci interactions of rs3918242 and rs3787268 in the MMP‐9 gene may confer a higher HT risk.

Why this matters

  • The identification of genetic variations that may confer a higher HT risk helps to identify at-risk patients, and leads to improved, and early, HT detection, and management/preventive treatment initiation.