Modeling Alzheimer’s disease stage duration: from preclinical to prodromal to dementia

Takeaway

  • The pace of Alzheimer’s disease (AD) progression from preclinical to prodromal AD and AD dementia is dependent on age, ranging from 15 years at age 80 to 24 years at age 60.

Why this matters

  • Estimates of disease progression are useful to define target populations for clinical trials and inform potential participants of prognosis prior to joining studies.