Modeling the pathogenicity of CASPR2 antibodies in the CNS symptoms of encephalitis


  • Contactin-associated protein 2 (CASPR2)-IgG antibodies, from one case of encephalitis, induced histological and behavioral changes in this mouse model, supporting a pathogenic role of CASPR2-IgG.

Why this matters

  • CASPR2-directed antibodies have been associated with symptoms of CNS disorders and neurodevelopmental disorders, but pathogenicity is yet to be evidenced with robust mouse models.