Molecular analyses of the hippocampus and cortex in patients with SUDEP

Takeaway

  • Molecular proteomic and transcriptomic signalling were largely similar in the brain tissues of patients with Sudden Unexpected Death in Epilepsy (SUDEP) and high-risk SUDEP, respectively. This is consistent with the various epileptic syndromes and associated comorbidities with SUDEP.

Why this matters

  • Neuropathological findings are generally indistinguishable between patients with SUDEP and non-SUDEP epilepsy. Proteomic and transcriptomic differences associated with SUDEP have not been evaluated thus far.

  • Results from this study have found no significant or limited molecular differences between SUDEP and non-SUDEP epilepsy, and calls for further evaluation with additional brain regions in an expanded cohort with different epileptic syndromes.