Molecular proteomic and transcriptomic signalling were largely similar in the brain tissues of patients with Sudden Unexpected Death in Epilepsy (SUDEP) and high-risk SUDEP, respectively. This is consistent with the various epileptic syndromes and associated comorbidities with SUDEP.
Why this matters
Neuropathological findings are generally indistinguishable between patients with SUDEP and non-SUDEP epilepsy. Proteomic and transcriptomic differences associated with SUDEP have not been evaluated thus far.
Results from this study have found no significant or limited molecular differences between SUDEP and non-SUDEP epilepsy, and calls for further evaluation with additional brain regions in an expanded cohort with different epileptic syndromes.