Motor activation during cognitive tasks in juvenile myoclonic epilepsy


  • Hyperactivation of the motor system during cognitive tasks in people with juvenile myoclonic epilepsy (JME) and their siblings implicates trait heritability and validates this as a JME endophenotype.

Why this matters

  • Juvenile myoclonic epilepsy is the most common genetic generalized epilepsy syndrome; myoclonus can be provoked by cognitive activities and may relate to motor hyperexcitability.

  • The functional magnetic resonance imaging (fMRI) findings of hyperactivation during different cognitive tasks in JME patients and their siblings could provide a quantitative trait of a potential endophenotype for this condition, impacting further study and management.