Motor connectivity during subthalamic nucleus deep brain stimulation

Takeaway

  • This study indicates that in those with Parkinson’s disease (PD) who have undergone subthalamic nucleus (STN) deep brain stimulation (DBS), DBS stimulates effective connectivity in cortico-basal ganglia loops at rest and modulates cortico-cerebellar motor systems during movement.

Why this matters

  • This in vivo study contributes to the body of literature determining the therapeutic mechanism underlying STN DBS and may help identify the best candidates for STN DBS.