Motor cortex stimulation and the relationship with neurotransmitters in neuropathic pain

Takeaway

  • Glycine and γ-aminobutyric acid (GABA) release in the periaqueductal gray (PAG) may be involved in the analgesia induced by motor cortex stimulation (MCS) in an animal model of neuropathic pain.

Why this matters ?

  • A greater understanding of the mechanisms underlying MCS-induced effects has the potential to identify new therapeutic targets for chronic neuropathic pain syndromes.