MRI biomarkers and partial least squares path modeling in Parkinson’s disease propagation

Takeaway

  • The neurodegeneration pattern in Parkinson’s disease (PD) patients with rapid eye movement (REM) sleep behavior disorder (RBD), but not without, as assessed by the partial least squares path modeling (PLS-PM) imaging-based model, is consistent with the Braak brainstem-to-cortex model.

Why this matters

  • Different models of neuropathologic propagation in PD are proposed, including the traditional Braak model, all thought to represent different patient phenotypes; however, the impact of RBD, a known PD comorbidity, on PD neurodegeneration models is unknown.

  • The discovery of discrete models for specific PD subtypes may support a deeper understanding of the clinical and pathologic heterogeneity of PD, aiding development of therapies targeted at specific subtypes and improving patient outcomes.