Multiple sclerosis risk genes and T cell composition in childhood

Takeaway

  • Multiple sclerosis (MS) polygenic risk scores (PRSs) were significantly associated with T cell composition in children from the general population.

Why this matters

  • T cells are thought to be the cell line that is predominantly influenced by genetic MS risk variants, with altered T cell function and composition detected in patients with MS.

  • Determining how polygenic risk factors for MS impact biological mechanisms prior to disease development may aid in the development of MS biomarkers that lead to earlier diagnoses and treatment.