Multisite postmortem validation of the Centiloid [11C]PIB-PET method to detect Aβ pathology

Takeaway 

  • The standardized Centiloid method for quantifying Amyloid beta-PET (Aβ-PET) imaging may improve cross-laboratory comparability and collaboration.

Why this matters

    Currently, there is a lack of standardization and high variability in Aβ-PET imaging analysis leading to difficulties when trying to compare study results or sharing data across institutions.