Mutations in amyloid β-processing genes suggest plasma amyloid β levels are an endophenotype of Alzheimer’s disease

Takeaway

  • Genome-wide association studies identify two significant loci in apolipoprotein E and BACE1 regions linked to plasma amyloid β levels in non‑demented people.

Why this matters

    This novel study explored the potential of plasma amyloid β levels as an endophenotype of Alzheimer's disease. The identified genetic determinants of plasma amyloid β levels could ultimately lead to new preventive or therapeutic targets against Alzheimer's disease.