Myelin imaging measures can predict cognitive impairment in multiple sclerosis

Takeaway

  • There is a link between myelin imaging measures and cognition, with lower myelin content by 11C-PIB uptake associated with worse cognitive status in people with multiple sclerosis.

Why this matters

    Cognitive impairment is a burden in multiple sclerosis and may be caused by myelin loss. This unique study employed a novel hybrid positron emission tomography-magnetic resonance imaging system to elucidate the relationship between myelin content and cognitive function in two phenotypes of multiple sclerosis. The findings suggest that global myelin content has an important impact on cognitive status; since magnetization transfer ratio predicted cognitive impairment, this could be a useful tool for evaluating people with multiple sclerosis at risk of cognitive decline.