Myeloid cell signatures linked to clinical features in people with amyotrophic lateral sclerosis

Takeaway

  • Distinctive clinical features in people with amyotrophic lateral sclerosis (ALS) are associated with differential myeloid cell signatures.

Why this matters

    A problematic aspect of ALS research is its heterogeneous nature; the ability to identify cell populations and markers may lead to targeted mechanistic studies and immunomodulation therapy development.