Myopathological features of DMSA subtypes in patients with dermatomyositis

Takeaway

  • Different dermatomyositis specific antibody (DMSA) subtypes of myxovirus-resistant protein A (MxA)-positive dermatomyositis are associated with unique myopathological features.

Why this matters

  • Clinical classification of dermatomyositis was revolutionized in 2018 by the European Neuromuscular Center following the discovery of at least five DMSA subtypes: anti-transcription intermediary factor 1-γ (TIF1-γ), anti-complex nucleosome remodeling histone deacetylase (Mi-2), anti-melanoma differentiation gene 5 (MDA5), anti-nuclear matrix protein 2 (NXP-2), and anti-small ubiquitin-like modifier-activating enzyme (SAE).

  • However, it remains unclear how these novel subtypes may track with differing myopathological characteristics.