Negative correlations between cerebrospinal fluid orexin-A and sleep stability in hypersomnolence

Takeaway

  • Cerebrospinal fluid orexin-A (ORX) has a stabilizing effect on sleep and wake bouts in people with hypersomnolence, as shown through polysomnography.

Why this matters

  • ORX levels could be used as a potential biomarker for hypersomnolence, aiding in future clinical trials and development of targeted treatments.