Nervous system and endothelial function in people with migraines


  • People with acute migraine with aura have higher flow-mediated dilation (FMD) values – a marker of endothelial dysfunction – than people without current headache in other migraine groups and those without migraine. Presence of headache may also be associated with increased sympathetic activity and decreased parasympathetic activity.

Why this matters

  • Previous studies have reported an association between migraines and endothelial dysfunction, but the relationship between autonomic nervous system dysfunction and migraine with aura has not been widely evaluated.

  • Evaluating endothelial and autonomic function in people with migraine during ictal and interictal periods can allow for more informed calculation of risk of vascular and nervous system disorders.