Neural surface antibodies in status epilepticus – are they associated with specific clinical features?

Takeaway

  • Neural surface antibodies (NS-Abs) were detected in 32% of patients with suspected autoimmune status epilepticus (SE), and were associated with specific preceding symptoms and inflammatory cerebrospinal fluid (CSF) markers.

Why this matters

  • SE is a medical emergency involving prolonged seizure activity. It has previously been associated with NS-Abs, but the overall rate of autoimmune cases has not been well studied.

  • Earlier identification of autoimmune SE will improve patient outcomes by informing treatment decisions.