Neuroanatomical abnormalities and gene mutations in paroxysmal kinesigenic dyskinesia

Takeaway

  • Clinical symptoms of paroxysmal kinesigenic dyskinesia (PKD) are associated with neural microstructural alterations, while PRRT2 gene mutations within PKD are associated with increased disease severity.

Why this matters

  • This study suggests neural microstructural abnormalities are associated with the PKD clinical phenotype instead of PRRT2 mutation status.