Individuals with amnestic and aphasic Alzheimer’s disease (AD) display different neurocognitive network patterns despite having the same underlying neuropathology of amyloid plaques and neurofibrillary tangles. This suggests that the clinical heterogeneity of this disease may depend on patterns of functional connectivity, as opposed to the molecular nature of the underlying pathology.
Why this matters
Little is known about how the disruption of certain neurocognitive networks differs by AD phenotype. Recent evidence suggests that some AD phenotypes are vulnerable to atrophy in certain neurocognitive networks. Understanding the different neurocognitive network patterns in amnestic and aphasic AD is necessary in characterizing the clinical heterogeneity of this disease.