Neurofibrillary tangle buildup in Nucleus Basalis of Meynert is Alzheimer’s disease subtype-specific


  • Neurofibrillary tangle accumulation in the nucleus basalis of Meynert could underlie extensive cholinergic deficits in Alzheimer’s disease, particularly the hippocampal sparing subtype.

Why this matters

  • The nucleus basalis of Meynert is known to be vulnerable to neurofibrillary tangles and plays significant role in targeted acetylcholinesterase inhibitor treatment.

  • These findings describe the differential involvement of this region between Alzheimer’s disease subtypes suggesting that this could influence the variable benefits of acetylcholinesterase inhibitor treatment, particularly in those with early-onset disease.