Neurofilament light as a prognostic biomarker in bacterial meningitis

Takeaway

  • Cerebrospinal fluid (CSF) concentrations of neurofilament light (NfL) were associated with unfavorable outcomes in bacterial meningitis.

Why this matters

  • Bacterial meningitis is associated with high mortality and morbidity, with approximately half of survivors experiencing neurologic sequelae.

  • NfL may be useful as a prognostic indicator of neuronal damage in this life-threatening disease, allowing better identification of those patients at highest risk of an unfavorable outcome.