Neuroinflammatory metabolites in fibromyalgia


  • Choline levels are typically higher in the anterior insular (alns) in people with fibromyalgia (FM) compared with healthy controls (HCs).

Why this matters

  • Using proton magnetic resonance spectroscopy (H-MRS), neuroinflammatory metabolites, myo-inositol and choline, have been found to be elevated in patients with chronic pain.

  • The role of these metabolites and their contribution to maladaptive brain changes in FM are not understood.