Neuromodulation in the management of migraine : a systematic review and meta-analysis


  • Several neurostimulatory techniques show promise in treating migraine, including remote electrical neuromodulation (REN) for acute treatment, invasive occipital nerve stimulation (ONS) for chronic prevention and a range of additional techniques for prevention.

Why this matters ?

  • Migraine is one of the most common neurological disorders worldwide, and the leading cause of disability in women aged 15 to 49. However, many patients are not optimally managed, due to limitations of available treatments, treatment-refractory disease, and reluctance to use pharmacotherapies.

  • A range of invasive and non-invasive neuromodulatory techniques have been studied for both the acute and preventative treatment of migraine, but no comprehensive systematic review of the evidence has been performed.