Neurodevelopmental differences across brain regions may contribute to seizure types and associated neuronal patterns in neonatal mice with hypoxic-ischemic encephalopathy (HIE).
Expression of cfos during hypoxic ischemia (HI) may contribute to seizure development.
These neuronal patterns may mirror those observed in human neonates with HIE.
Why this matters
Seizures are frequent among neonates with HIE; however, the neurological circuits driving epileptic episodes are unknown.
This study brings us closer to understanding the relationship between cfos and seizure characteristics among this population.