Neuronal activity in hypoxic-ischemic seizures


  • Neurodevelopmental differences across brain regions may contribute to seizure types and associated neuronal patterns in neonatal mice with hypoxic-ischemic encephalopathy (HIE).

  • Expression of cfos during hypoxic ischemia (HI) may contribute to seizure development.

  • These neuronal patterns may mirror those observed in human neonates with HIE.

Why this matters

  • Seizures are frequent among neonates with HIE; however, the neurological circuits driving epileptic episodes are unknown.

  • This study brings us closer to understanding the relationship between cfos and seizure characteristics among this population.