Neuronal association of Plexin D1 in idiopathic painful trigeminal neuropathy

Takeaway

  • Plexin D1 IgG binds to both pain-conducting small trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons and can be present in idiopathic painful trigeminal neuropathy (IPTN); further research is required to better understand the mechanism of this association.

Why this matters

  • IPTN is characterized by facial pain which correlates with the trigeminal nerve and is of unknow mechanism.

  • Further research into the association between Plexin D1 IgG and IPTN and TG neurons may clarify its clinical impact.