Neutrophil rate and sex effects on survival in amyotrophic lateral sclerosis


  • Higher baseline neutrophil counts are associated with shorter survival in female participants with amyotrophic lateral sclerosis (ALS).

Why this matters

  • The pathophysiological mechanisms of ALS are not fully understood; however, the immune system is known to play various roles in both exacerbation and reduction of symptoms, and is thus currently a therapeutic target.

  • The shorter survival time in female ALS patients suggests that the interaction between immunity and sex in this condition should be considered in relation to targeted therapy development in ALS; however, further study is required for validation.