Takeaway
In a real-world setting, a roving Expanded Disability Status Scale (EDSS) score, as opposed to a fixed baseline score, appears to be more sensitive for detecting confirmed disability-worsening events unrelated to relapse in individuals with relapse-remitting multiple sclerosis (RRMS).
Why this matters
The prevention of long-term disability accrual is the goal of multiple sclerosis treatment, and a roving EDSS score may better capture the accumulation of disability-events, including those unrelated to relapse.