No relationship between serum homocysteine and middle cerebral artery stenosis


  • Based on the lack of correlation between serum homocysteine (HCY) levels and middle cerebral artery (MCA) stenosis, investigators concluded that therapy to lower HCY is more likely to be effective in primary stroke prevention.

Why this matters

  • Elevated serum HCY level is a risk factor for vascular disease, but evidence on effects of HCY-lowering interventions for preventing primary or secondary vascular events remains unclear.

  • Evidence on the relationship between HCY and MCA stenosis is lacking but may help guide use of HCY-lowering interventions for primary and/or secondary stroke prevention.