Nodal and para-nodal antibodies in genetic neuropathies

Takeaway

  • Nodal and para-nodal antibodies were not detected in patients with hereditary neuropathies included in the study.

Why this matters ?

  • Nodal and para-nodal antibodies were initially reported to be highly specific disease markers in chronic inflammatory demyelinating polyradiculoneuropathy.

  • More recently, small-scale studies reported nodal and para-nodal antibodies in idiopathic and genetic neuropathies, calling to question the role of such antibodies in the pathologies of genetic, idiopathic and inflammatory disease.