Non-amyloid logopenic is the most common primary progressive aphasia variant linked to progranulin mutations


  • Progranulin mutation in primary progressive aphasia could exert a harmful effect on distinct neocortical networks.

Why this matters

  • This is the first in-depth characterization in a large cohort of primary progressive aphasia variants associated with progranulin mutations.

  • The findings further our understanding of the linguistic spectrum in primary progressive aphasia, suggesting that progranulin mutation testing would be useful in this population, especially in view of upcoming progranulin mutation-targeted therapies.