Non-invasive characterization of the epileptogenic zone in drug-resistant focal epilepsy

Takeaway

  • Non-invasive source localization for epileptogenic zone characterization is more accurate when performed independently, not combined, on high-density electroencephalography (HDEEG) and magnetoencephalography (MEG) synchronously-acquired interictal and ictal discharges.

Why this matters

  • Surgical resection of the epileptogenic zone can provide long-term seizure freedom in people with drug-resistant focal epilepsy, but current non-invasive methods for localization of this zone are insufficient when MRI shows no lesion or an extensive lesion.