Non-linear relationship between plasma amylin levels and risk of Alzheimer’s disease


  • The association between plasma amylin concentrations and incidence of Alzheimer’s disease (AD) is U-shaped, rather than linear; high plasma amylin levels have a protective association with temporal lobe brain volume.

Why this matters

  • The findings support preclinical observations that, although amylin is beneficial for the aging brain, very high concentrations may lead to amylin aggregation and increase the risk of AD. It is therefore important to monitor plasma amylin levels in the elderly, particularly those at risk of AD, such as APOE4 carriers.