Non-pharmacological approaches to pediatric drug-resistant epilepsy


  • This retrospective study of pediatric drug-resistant epilepsy (DRE) showed that combination treatment of ketogenic diet (KD) and vagus nerve stimulation (VNS) result in continued reduction in seizure frequency over time.

Why this matters

  • The burden of DRE, where anti-epileptic drugs (AEDs) fail to control seizures, is high and associated with multiple comorbid conditions that lead to poor quality of life.

  • Studies have shown that both a high fat diet and VNS are separately effective in treating people with DRE; however, the mechanisms of action or a possible effect of combination of KD and VNS are not clear.