Novel Approach Used in Definition of Complex Pathogenic Mechanisms Underlying Multiple Sclerosis


  • A close link between gray matter (GM) atrophy patterns and white matter (WM) damage in multiple sclerosis (MS) was found using a novel data analysis approach. In turn, sensorimotor and posterior cortex patterns were partially independent from WM damage and deemed potentially related to primary mechanisms.

Why this matters ?

  • Source-based morphometry (SBM) is a novel, model-free, and data-driven multivariate approach that allows for the grouping of structural abnormalities in the brain into spatial patterns.

  • Using this approach, the investigators found a number of clinically relevant patterns that showed correlation with physical disability.