Novel plasma microRNAs are non-invasive biomarkers of Charcot-Marie-Tooth Disease Type 1A


  • A newly identified group of plasma microRNAs are elevated in people with Charcot-Marie-Tooth Disease, type 1A.

Why this matters

    Monitoring Charcot-Marie-Tooth Disease, type 1A often requires invasive nerve or muscle biopsies. These important findings provide Class III evidence that a set of plasma microRNAs could be used as alternative biomarkers of disease activity. Some of the newly identified microRNAs may reveal Schwann cell processes that underlie the pathogenesis of the disease.