Novel prognostic factors for patients with brain metastases undergoing radiation therapy

Takeaway

  • Systemic therapy before radiation therapy (RT) and the type of systemic therapy after RT independently predicted overall survival (OS) in patients with brain metastases undergoing first RT.

Why this matters

  • Extracranial disease, performance status, age, cancer diagnosis and number of brain metastases are established prognostic factors in patients with brain metastases treated with RT.

  • Limited studies have identified that receipt of chemotherapy is a strong predictor of survival in melanoma and bladder cancer, but no study has incorporated the use of systemic therapy in a prognostic scoring system.