Nuclear factor one transcription factors induce cellular differentiation in astrocytomas


  • In vivo analyses in glioblastoma xenografts demonstrated that expression of either nuclear factor one A (NFIA) or nuclear factor one B (NFIB) sufficiently promoted tumor cell differentiation.

Why this matters

    A malignant astrocytoma with a large expression of NFI correlated with more differentiated cells, which leads to better prognosis. Altering the behavior of high-grade astrocytomas via differentiation is a potential therapeutic strategy.