Nwd1, an innate immune system protein, is expressed predominantly in excitatory versus inhibitory neurons, which may contribute to seizure activity.
Silencing Nwd1 markedly reduces neuronal hyperexcitability seizure onset.
Why this matters
Findings provide novel insights into the underlying biology of seizures, through characterization of the role of Nwd1 in seizure activity.
This could provide a new therapeutic target for treatment of seizures.