Nwd1 and its role in epilepsy


  • Nwd1, an innate immune system protein, is expressed predominantly in excitatory versus inhibitory neurons, which may contribute to seizure activity.

  • Silencing Nwd1 markedly reduces neuronal hyperexcitability seizure onset.

Why this matters

  • Findings provide novel insights into the underlying biology of seizures, through characterization of the role of Nwd1 in seizure activity.

  • This could provide a new therapeutic target for treatment of seizures.