Obesity paradox in initial ischemic stroke symptoms and functional outcomes at discharge


  • In people with ischemic stroke and non-valvular atrial fibrillation (NVAF), underweight people had more severe symptoms and higher risk of poor functional outcomes than those of normal weight; overweight obese people had milder symptoms and no differences in outcomes.

Why this matters

    Results suggest factors associated with being overweight may confer some neuroprotective properties in stroke, warranting investigation of whether determining factors are those more common in this group (e.g. non-smoking, cohabitation) or inherent factors such as greater metabolic reserve.