Observing mitochondrial and glycolytic impairment in living patients with Alzheimer’s Disease

Takeaway

  • The novel positron emission tomography (PET) probe [18F]BCPP-EF which binds to mitochondrial proteins, showed that mitochondrial dysfunction in the parahippocampus is present in early-stage Alzheimer’s Disease (AD).

Why this matters ?

    Post-mortem and in vitro studies suggest mitochondrial dysfunction plays a role in the pathogenesis of AD however, little is known about mitochondrial changes in people living with AD.